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Category: 7TM ReceptorsarrowHistamine ReceptorsarrowH3 and H4 ReceptorsarrowAgonists
Cat.No. Product Name
2494 VUF 8430 dihydrobromide
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VUF 8430 dihydrobromide
Chemical Name: 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester dihydrobromide

Biological Activity:

High affinity (pKi = 7.5), potent histamine H4 receptor full agonist (pEC50 = 7.3). Displays moderate affinity for H3 receptors (pKi = 6.0) and weak partial agonist activity at H2 receptors.

Technical Data:

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M.Wt: 323.05
Formula: C4H11N5S.2HBr
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Water and to 100 mM in DMSO
CAS No: [98021-17-1]

Resources:

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    • Certificate of Analysis / MSDS:

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    Product/Material Safety Data Sheet: View current batch

    References:

    Sterk et al (1986) The influence of guanidio and isothiourea groups in histaminergic compounds on H2-activity. Agents Actions 18 137. Lim et al (2006) Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J.Med.Chem. 49 6650.
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    Keywords: VUF 8430 Dihydrobromide, Histamine Receptors, Potent, High Affinity H4 Agonist, VUF8430 Dihydrobromide, Tocris Bioscience
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