U 99194 Maleate | Dopamine Receptors | Potent, Selective D3 Antagonist | PNU 99194 | U99194 Maleate

Category:

7TM Receptors

Dopamine Receptors

D2-like Receptors

D3-selective

Cat.No.

Product Name

1357

U 99194 maleate

Alternative name(s):

PNU 99194

U 99194 maleate C17H27NO2.C4H4O4 2,3-Dihydro-5,6-dimethoxy-N, N-dipropyl-1H-inden-2-amine maleate

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U 99194 maleate

Chemical Name: 2,3-Dihydro-5,6-dimethoxy-N, N-dipropyl-1H-inden-2-amine maleate

Biological Activity:

Potent, selective D₃ antagonist. K_i values are 160, 2281 and > 10000 nM for human cloned D₃, D₂ and D₄ receptors respectively.

Technical Data:

M.Wt:	393.48
Formula:	C₁₇H₂₇NO₂.C₄H₄O₄
Storage:	Store at RT
Solubility:	Soluble to 25 mM in Water
Purity:	>98%
CAS No:	[83598-46-3]

Resources:

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References:

Audinot et al (1998) A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D₃ receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J.Pharmacol.Exp.Ther. 287 187. Clifford and Waddington (1998) Heterogeneity of behavioural profile between three putative selective D₃ dopamine receptor antagonists using an ethologically based approach. Psychopharmacology 136 284. LaHoste et al (2000) Dopamine D₁ receptors synergize with D₂, but not D₃ or D₄, receptors in the striatum without the involvement of action potentials. J.Neurosci. 20 6666.

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Keywords: U 99194 Maleate, Dopamine Receptors, Potent, Selective D3 Antagonist, PNU 99194, U99194 Maleate, Tocris Bioscience

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Dopamine Receptors
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