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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowGABAA ReceptorsarrowAntagonists
Cat.No. Product Name
2745 U 93631
Price and Availability

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U 93631
Chemical Name: 4,5-Dihydro-4,4-dimethyl-imidazo[1,5-a]quinoxaline-3-ca rboxylic acid 1,1-dimethylethyl ester

Biological Activity:

GABAA receptor antagonist that binds the picrotoxin site and stabilises the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism.

Technical Data:

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M.Wt: 299.37
Formula: C17H21N3O2
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO and to 100 mM in Ethanol
Purity: >99%
CAS No: [152273-12-6]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Dillon et al (1993) U-93631 causes rapid decay of γ-aminobutyric acid-induced chloride currents in recombinant rat γ-aminobutyric acid type A receptors. Mol.Pharmacol. 44 860. Dillon et al (1995) [4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability. J.Pharmacol.Exp.Ther. 272 597. Das et al (2003) The GABAA receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors. Neuropharmacol. 44 431.
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    Keywords: U 93631, Ligand-gated Ion Channels, GABAA Receptor Antagonist, U93631, Tocris Bioscience
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