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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowGABAA ReceptorsarrowOther
Cat.No. Product Name
2734 U 89843A
Alternative name(s): PNU 89843
Price and Availability

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U 89843A
Chemical Name: 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyr imidine hydrochloride

Biological Activity:

Positive allosteric modulator of GABAA receptors. Enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity.

Technical Data:

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M.Wt: 321.85
Formula: C16H23N5.HCl
Storage: Desiccate at RT
Solubility: Soluble to 25 mM in Water and to 50 mM in DMSO
Purity: >99%
CAS No: [157013-32-6]

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    References:

    Bundy et al (1995) Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity. J.Med.Chem. 38 4161. Haesook et al (1995) U-89843A is a novel allosteric modulator of γ-aminobutyric acidA receptors. J.Pharmacol.Exp.Ther. 275 1390. Rohn et al (1996) Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals. Biochem.Pharmacol. 51 471.
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    Keywords: U 89843A, Ligand-gated Ion Channels, Positive Allosteric Modulator Of GABAA, PNU 89843, U89843A, Tocris Bioscience
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