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Category:
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Other Activities Miscellaneous Compounds
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Cat.No.
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Product Name
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2750 |
U 83836E
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| Alternative name(s): |
PNU 83836E |
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Price and Availability
Click here for full price details of
U 82836E
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Chemical Name:
(2R)-2-[[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-pipe
razinyl]methyl]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-be
nzopyran-6-ol dihydrochloride |
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Biological Activity:
Free radical scavenger and antioxidant; second
generation lazaroid that inhibits iron-dependent lipid peroxidation (IC50
= 1.5 μM).
Displays neuroprotective activity in a mouse head injury model (MHI) and causes
a reduction in cyanide-induced cell death in rat cortical neurons.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Jacobsen et al
(1992) 2-(aminomethyl)chromans that inhibit iron-dependent lipid peroxidation
and protect against central nervous system trauma and ischemia. J.Med.Chem. 35
4464. Altavilla et al (1998) Inhibition of tumour necrosis factor
and reversal of endotoxin-induced shock by U-83836E, a 'second generation'
lazaroid in rats. Br.J.Pharmacol. 124 1293. Vignes and Hugon
(2006) In vitro efficacy of three lazaroids in a model of acute chemical neuronal
hypoxia. Neurosci.Lett. 407 171.
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View related products by Pharmacological Action
or by Research Area
Keywords: U 82836E, Antioxidant; Inhibits Lipid Peroxidation, PNU 83836E, U82836E, Tocris Bioscience
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