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Category: EnzymesarrowEsterasesarrowPhospholipase
Cat.No. Product Name
1268 U 73122
Price and Availability

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U 73122

Other Information:

Sold with the permission of Pharmacia
Chemical Name: 1-[6-[[(17b)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino ]hexyl]-1H-pyrrole-2,5-dione

Biological Activity:

Phospholipase C inhibitor. Inhibits agonist-induced platelet aggregation with IC50 values of 1-5 μM. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces (IC50 < 50 nM).

Technical Data:

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M.Wt: 464.65
Formula: C29H40N2O3
Storage: Store at RT
Solubility: Soluble to 2 mM in Ethanol and to 5 mM in DMSO
Purity: >98%
CAS No: [112648-68-7]

Resources:

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    References:

    Bleasdale et al (1990) Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J.Pharmacol.Exp.Ther. 255 756. Smith et al (1996) U-73122: a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces and adhesion-related effector functions. J.Pharmacol.Exp.Ther. 278 320.
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    Keywords: U 73122, Esterases, Phospholipase C Inhibitor, U73122, Tocris Bioscience
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