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Category:
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Cellular Processes and Components Signal TransductionHedgehog Signalling
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Cat.No.
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Product Name
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1638 |
U 18666A
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Price and Availability
Click here for full price details of
U 18666A
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Chemical Name:
(3b)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one
hydrochloride |
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Biological Activity:
Inhibitor
of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog
(hh) signalling. Reduces serum sterol levels in rats in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Cenedella et al (1980) Concentration-dependent
effects of AY-9944 and U18666A on sterol synthesis in brain. Biochem.Pharmacol.
29 2751. Liscum and Faust (1989) The intracellular
transport of low density lipoprotein-derived cholesterol is inhibited in
Chinese hamster ovary cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one.
J.Biol.Chem. 264 11796. Incardona et al (2000)
Cyclopamine inhibition of sonic hedgehog signal transduction is not mediated
through effects on cholesterol transport. Dev.Biol. 224 440.
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Keywords: U 18666A, Signal Transduction, Inhibitor Of Hedgehog (hh) Signalling. Also Inhibits Cholesterol Synthesis, U18666A, Tocris Bioscience
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