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Category:
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Ion Channels Potassium ChannelsCa2+-Activated Potassium Channels
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Cat.No.
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Product Name
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1310 |
UCL 1684
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Price and Availability
Click here for full price details of
UCL 1684
Other Information:
Sold
with the permission of University College, London
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Chemical Name:
6,12,19,20,25,26-Hexahydro-5,27:13,18:21,24-trietheno-1
1,7-metheno-7H-dibenzo [b,n]
[1,5,12,16]tetraazacyclotricosine-5,13-diium dibromide |
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Biological Activity:
Highly potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated
K+ channel (SKCa) (IC50 = 3 nM in rat
sympathetic neurons). Blocks hSK1 and rSK2 channels expressed in HEK 293 cells
with IC50 values of 762 and 364 pM respectively.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Campos Rosa et al (2000) Synthesis, molecular modeling, and
pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic
blockers of the apamin-sensitive Ca2+-activated K+
channel. J.Med.Chem. 43 420. Malik-Hall et al
(2000) Compounds that block intermediate-conductance (IKCa) and
small-conductance (SKCa) calcium-activated potassium channels.
Br.J.Pharmacol. 129 1431. Strobaek et al (2000)
Pharmacological characterization of small-conductance Ca2+-activated
K+ channels stably expressed in HEK 293 cells. Br.J.Pharmacol. 129
991.
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View related products by Pharmacological Action
or by Research Area
Keywords: UCL 1684, Potassium Channels, Highly Potent Blocker Of SKCa, UCL1684, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Purity To Rely On
When choosing reagents for an experiment, the prime consideration is often to obtain the highest quality products available.
Unlike other suppliers, our in-house QC team carry out multiple analytical tests to thoroughly assess the purity of our reagents before they are offered for sale.
This accurate purity data is available on a batch-specific basis for every product via our website. At Tocris we work hard to ensure that we always supply to the highest possible standards of purity.
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