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Category:
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7TM Receptors Chemokine ReceptorsCCR
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Cat.No.
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Product Name
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2757 |
UCB 35625
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Price and Availability
Click here for full price details of
UCB 35625
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Chemical Name:
1,4-trans-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro
-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium
iodide |
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Biological Activity:
Potent chemokine CCR1 and CCR3 receptor
antagonist. Inhibits MIP-1α-induced
chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3
transfectants (IC50 values are 9.57 and 93.8 nM respectively).
Antagonises CCR3-mediated entry of HIV-1 isolate 89.6 into NP-2 cells (IC50
= 57 nM). Isomer of J 113863 (Cat. No. 2595).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Sabroe et al
(2000) A small molecule antagonist of chemokine receptors CCR1 and CCR3.
J.Biol.Chem. 275 25985. Lopes de Mendonca et al
(2005) Site-directed mutagenesis of CC chemokine receptor 1 reveals the
mechanism of action of UCB 35625, a small molecule chemokine receptor
antagonist. J.Biol.Chem. 280 4808.
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View related products by Pharmacological Action
or by Research Area
Keywords: UCB 35625, Chemokine Receptors, Potent CCR1 & CCR3 Antagonist, UCB35625, Tocris Bioscience
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