Chemical Name:a-Methyl-3-methyl-4-phosphonophenylglycine
Biological Activity:
A selective group III mGlu receptor
antagonist (apparent Kd values are 5.1 and 488 μM
for group III and group II mGlu receptors respectively; IC50 > 1
mM for group I, NMDA, AMPA and kainate receptors).
Conway et al (2001) Synthesis of phenylglycine derivatives as potent and
selective antagonists of group III metabotropic glutamate receptors.
Bioorg.Med.Chem.Lett. 11 777. Milleret al (2003)
Phenylglycine derivatives as antagonists of group III metabotropic glutamate
receptors expressed on neonatal rat primary afferent terminals. Br.J.Pharmacol.
139 1523.
