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Category:
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7TM Receptors Opioid ReceptorsKappa ReceptorsAgonists
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Cat.No.
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Product Name
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0498 |
U-54494A hydrochloride
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Price and Availability
Click here for full price details of
U-54494A hydrochloride
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Chemical Name:
cis-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cycl
ohexyl]benzamide hydrochloride |
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Biological Activity:
κ-opioid agonist and anticonvulsant. Perhaps acts as an NMDA
antagonist.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Voigtlander et al (1987) U-54494A: a unique anticonvulsant related to kappa
opioid agonists. J.Pharmacol.Exp.Ther. 243 542. Proietti et
al (1991) In vitro depressant effects of U-54494A, an anticonvulsant
related to kappa opioids in the hippocampus. Neuropharmacology 30
637. Sethy and Sage (1992) Modulation of release of acetylcholine from
the striatum by a proposed excitatory amino acid antagonist U-54494A:
comparison with known antagonists, diazepam and phenytoin. Neuropharmacology
31 111.
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Keywords: U-54494A Hydrochloride, Opioid Receptors, K Agonist, U54494A Hydrochloride, Tocris Bioscience
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