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Category: 7TM ReceptorsarrowOpioid ReceptorsarrowKappa ReceptorsarrowAgonists
Cat.No. Product Name
0495 (±)-U-50488 hydrochloride  
Price and Availability

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(±)-U-50488 hydrochloride
Chemical Name: trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cy clohexyl]benzeneacetamide hydrochloride

Biological Activity:

Selective κ-opioid agonist. At higher concentrations blocks Na+ channels. See separate isomers.

Technical Data:

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M.Wt: 405.79
Formula: C19H26Cl2N2O.HCl
Storage: Desiccate at RT
Purity: >99%
CAS No: [67198-13-4]

Resources:

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    References:

    Suarez-Roca and Maixner (1983) Activation of kappa opioid receptors by U-50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices. J.Pharmacol.Exp.Ther. 264 648. Pugsley et al (1992) Cardiovascular actions of the κ-agonist, U-50-488H, in the absence and presence of opioid receptor blockade. Br.J.Pharmacol. 105 521. Pao-Luh Tao et al (1994) U-50,488 blocks the development of morphine tolerance and dependence at a very low dose in guinea pigs. Eur.J.Pharmacol. 256 281. Su et al (1998) Blockade of the development of morphine tolerance by U-50,488, an AVP antagonist or MK 801 in the rat hippocampal slice. Br.J.Pharmacol. 123 625.
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    Keywords: (±)-U-50488 Hydrochloride, Opioid Receptors, Standard Selective K Agonist, U50488 Hydrochloride, Tocris Bioscience

    Literature in this Area
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