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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowAcetylcholine (Nicotinic) ReceptorsarrowAntagonists
Cat.No. Product Name
2820 (+)-Tubocurarine chloride
Price and Availability

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(+)-Tubocurarine chloride
Chemical Name: 2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29 -dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,1 2-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosin o[2,3,4-ij]isoquinolinium chloride hydrochloride

Biological Activity:

Competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.

Technical Data:

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M.Wt: 681.65
Formula: C37H41ClN2O6.HCl
Storage: Store at +4°C
Solubility: Soluble to 25 mM in Water and to 10 mM in DMSO
Purity: >99%
CAS No: [57-94-3]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Pederson and Cohen (1990) d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor. Proc.Natl.Acad.Sci.USA 87 2785. Peters et al (1990) Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci.Letts. 110 107. Wotring and Yoon (1995) The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons. Neurosci. 67 293.
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    Keywords: (+)-Tubocurarine Chloride, Ligand-gated Ion Channels, Nicotinic Receptor Antagonist, Tubocurarine Chloride, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Nicotinic ACh Receptors
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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    Product Feature
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