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Category: EnzymesarrowDeacetylasesarrowHistone Deacetylase
Cat.No. Product Name
1406

Trichostatin A

Price and Availability

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Trichostatin A
Chemical Name: (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-di methyl-7-oxo-2,4-heptadienamide

Biological Activity:

Selective and potent inhibitor of histone deacetylase (Ki = 3.4 nM). Active in vivo. Potential anti-cancer agent.

Technical Data:

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M.Wt: 302.37
Formula: C17H22N2O3
Storage: Desiccate at -20°C
Solubility: Soluble to 10 mM in Ethanol and to 50 mM in DMSO
CAS No: [58880-19-6]

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    References:

    Yoshida et al (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J.Biol.Chem. 165 17174. Wharton et al (2000) Inhibition of mitogenesis in Balb/c-3T3 cells by trichostatin A. J.Biol.Chem. 275 33981. Vigushin et al (2001) Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin.Cancer Res. 7 971.
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    Keywords: Trichostatin A, Deacetylases, Histone Deacetylase Inhibitor, Tocris Bioscience
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