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Category:
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Other Activities Miscellaneous Compounds
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Cat.No.
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Product Name
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1098 |
Tranilast
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Price and Availability
Click here for full price details of
Tranilast
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Chemical Name:
2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benz
oic acid |
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Biological Activity:
Anti-allergic via inhibition of chemical mediator release from
mast cells. Most recently shown to be an effective inhibitor of angiogenesis.
Demonstrated to antagonise the effects of angiotensin II on human arteries,
possibly by an interaction at the level of the AT1 receptor.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Miyazawa et al (1996) Antiproliferative and c-myc mRNA suppressive
effects of tranilast on newborn human vascular smooth muscle cells in culture.
Br.J.Pharmacol. 118 915. Hishikawa et al (1996)
Tranilast restores cytokine-induced nitric oxide production against platelet
derived growth factor in vascular smooth muscle cells. J.Cardiovasc.Pharmacol. 28
200. Isaji et al (1997) Tranilast inhibits the proliferation,
chemotaxis and tube formation of human microvascular endothelial cells in
vitro and angiogenesis in vivo. Br.J.Pharmacol. 122
1061. Jin et al (1998) Tranilast, an anti-allergic drug,
possesses antagonistic potency to angiotensin II. Eur.J.Pharmacol. 361
199.
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or by Research Area
Keywords: Tranilast, Anti-allergic, Inhibits Release From Mast Cells, Tocris Bioscience
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