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Category:
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Transporters Neurotransmitter TransportersAdrenergic Transporters
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Cat.No.
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Product Name
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2011 |
Tomoxetine hydrochloride
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| Alternative name(s): |
Atomoxetine |
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LY 139603 |
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Price and Availability
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Tomoxetine hydrochloride
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Chemical Name:
(R)-N-Methyl-g-(2-methylphenoxy)-benzenepropanamine
hydrochloride |
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Biological Activity:
Potent and selective noradrenaline re-uptake
inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of
radioligand binding to human NET, SERT and DAT respectively). Displays minimal
affinity for a range of other neurotransmitter receptors and transporters (Ki
> 1 μM).
Antidepressant.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Wong et al (1982) A new inhibitor
of norepinephrine uptake devoid of affinity for receptors in rat brain.
J.Pharmacol.Exp.Ther. 222 61. Bymaster et al (2002)
Atomoxetine increases extracellular levels of norepinephrine and dopamine in
prefrontal cortex of rat: a potential mechanism for efficacy in attention
deficit/hyperactivity disorder. Neuropsychopharmacology 27 699.
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or by Research Area
Keywords: Tomoxetine Hydrochloride, Neurotransmitter Transporters, Potent, Selective Noradrenaline Re-uptake Inhibitor, Atomoxetine, LY 139603, Tocris Bioscience
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