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Category: Cellular Processes and ComponentsarrowSignal TransductionarrowCytokine and NFkB SignallingarrowCytokines
Cat.No. Product Name
0652 Thalidomide  
Price and Availability

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Thalidomide
Chemical Name: N-(2,6-dioxo-3-piperidinyl)phthalimide

Biological Activity:

Teratogen, sedative-hypnotic with inherent anti-inflammatory properties. A selective inhibitor of tumor necrosis factor α (TNF-α) synthesis.

Technical Data:

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M.Wt: 258.23
Formula: C13H10N2O4
Storage: Store at RT
Solubility: Soluble to 25 mM in DMSO
Purity: >99%
CAS No: [50-35-1]

Resources:

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    • Certificate of Analysis / MSDS:

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    References:

    Merck Index 12 9390. Sampaio et al (1991) Thalidomide selectively inhibits tumor necrosis factor α production by stimulated human monocytes. J.Exp.Med. 173 699. Makonkawkeyoon et al (1993) Thalidomide inhibits the replication of human-immunodeficiency-virus type 1. Proc.Natl.Acad.Sci.USA 90 5974. Kanbayashi et al (1996) Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy. Neuroreport 7 1881. Boireau et al (1997) Thalidomide reduces MPTP-induced decrease in striatal dopamine levels in mice. Neurosci.Lett. 234 123.
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    Keywords: Thalidomide, Signal Transduction, TNF-a Synthesis Inhibitor, Tocris Bioscience
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