Tetrodotoxin | Sodium Channels | Na+ Channel Blocker | TTx

Category:

Ion Channels

Sodium Channels

Voltage-gated Sodium Channels

Cat.No.

Product Name

1078

Tetrodotoxin

Alternative name(s):

TTx

Tetrodotoxin C11H17N3O8 Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol

Price and Availability

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Tetrodotoxin

Other Information:

Chemical Name: Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethan o-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pen tol

Biological Activity:

Selective inhibitor of Na⁺ channel conductance. Binding is reversible and of high affinity (K_d = 1-10 nM). Blocks in a use-dependent manner.

Technical Data:

M.Wt:	319.27
Formula:	C₁₁H₁₇N₃O₈
Storage:	Desiccate at -20°C
Solubility:	Soluble to 3 mM in Acidic buffer (pH 4.8)
CAS No:	[4368-28-9]

Resources:

Certificate of Analysis / MSDS:

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References:

Merck Index 12 9382. Kao (1972) Pharmacology of tetrodotoxin and saxitoxin. Fed.Proc. 31 1117. Kao (1986) Structure-activity relations of tetrodotoxin, saxitoxin, and analogues. Ann.N.Y.Acad.Sci. 479 52. Gleitz et al (1996) The protective action of tetrodotoxin and (±)-kavain on anaerobic glycolysis, ATP content and intracellular Na⁺ and Ca²⁺ of anoxic brain vesicles. Neuropharmacology 35 1743.

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Keywords: Tetrodotoxin, Sodium Channels, Na+ Channel Blocker, TTx, Tocris Bioscience

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