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Category: EnzymesarrowKinasesarrowBTK
Cat.No. Product Name
1405 (-)-Terreic acid
Price and Availability

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Terreic acid
Chemical Name: (1R,6S)-3-Hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-en e-2,5-dione

Biological Activity:

Selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCβII and BTK (IC50 ~ 30 μM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.

Technical Data:

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M.Wt: 154.12
Formula: C7H6O4
Storage: Store at +4°C
Solubility: Soluble to 20 mM in Water
Purity: >99%
CAS No: [121-40-4]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Yamamoto et al (1980) Studies on terreic acid. Jpn.J.Antibiot. 33 320. Subramanian et al (1982) In vivo and in vitro studies on the binding nature of terreic acid with macromolecules such as protein and nucleic acids. Toxicol.Lett. 10 249. Kawakami et al (1999) Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc.Natl.Acad.Sci.USA 96 2227.
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    Keywords: Terreic Acid, Kinases, Selective Inhibitor Of BTK, Tocris Bioscience
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