Taxol | Cytoskeleton & Motor Proteins | Promotes Assembly & Inhibits Disassembly Of Microtubules | Paclitaxel

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Category:

Cellular Processes and Components

Cytoskeleton and Motor Proteins

Microtubules

Cat.No.

Product Name

1097

Taxol

Alternative name(s):

Paclitaxel

Taxol C47H51NO14 [2aR-[2aa,4b,4ab,6a,9a(aR*,bS*),11a,12a,12aa,12ba]]-b-(Benzoylamino)-a-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl

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Taxol

Chemical Name: [2aR-[2aa,4b,4ab,6a,9a(aR*,bS*),11a,12a,12aa,12ba]]-b-( Benzoylamino)-a-hydroxy-6,12b-bis(acetyloxy)-12-(benzoy loxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11- dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H- cyclodeca[3,4]benz[1,2-b]oxet-9-yl

Biological Activity:

Antitumour agent; promotes and stabilises tubulin polymerisation, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.

Technical Data:

M.Wt:	853.92
Formula:	C₄₇H₅₁NO₁₄
Storage:	Desiccate at +4°C
Solubility:	Soluble to 25 mM in Ethanol and to 100 mM in DMSO
Purity:	>99%
CAS No:	[33069-62-4]

Resources:

Certificate of Analysis / MSDS:

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References:

Merck Index 12 7117. McGuire et al (1989) Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann.Int.Med. 111 273. Rowinsky et al (1990) Taxol: a novel investigational antimicrotubule agent. Int.J.Cancer 82 1247. Rao et al (1999) Characterization of the taxol binding site on the microtubule. J.Biol.Chem. 274 37990. Park et al (2004) Taxol induces caspase-10-dependent apoptosis. J.Biol.Chem. 279 51057.

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Keywords: Taxol, Cytoskeleton & Motor Proteins, Promotes Assembly & Inhibits Disassembly Of Microtubules, Paclitaxel, Tocris Bioscience

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