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Category:
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Enzymes Phosphodiesterases
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Cat.No.
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Product Name
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1676 |
T 0156 hydrochloride
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Price and Availability
Click here for full price details of
T 0156
Other Information:
Sold with
the permission of Tanabe Seiyaku Co.
Ltd
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Chemical Name:
1,2-Dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2
-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-nap
hthyridine-3-carboxylic acid methyl ester hydrochloride |
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Biological Activity:
Potent
and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than
sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156
and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1-4
respectively). Selective over 30 other enzymes and receptors (IC50
> 10 μM) and potentiates electrical field stimulation-induced
relaxation of isolated rabbit corpus cavernosum. Active in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Mochida et al (2002) Enzymological
and pharmacological profile of T-0156, a potent and selective phosphodiesterase
type 5 inhibitor. Eur.J.Pharmacol. 456 91. Mochida et
al (2004) T-0156, a novel phosphodiesterase type 5 inhibitor, and
sildenafil have different pharmacological effects on penile tumescence and
electroretinogram in dogs. Eur.J.Pharmacol. 485 283.
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or by Research Area
Keywords: T 0156, Phosphodiesterases, Highly Potent, Selective PDE5 Inhibitor, T0156, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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