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Category:
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Ion Channels Potassium ChannelsCa2+-Activated Potassium Channels
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Cat.No.
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Product Name
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2946 |
TRAM 34
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Price and Availability
Click here for full price details of
TRAM 34
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Chemical Name:
1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole |
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Biological Activity:
Highly selective inhibitor of intermediate
conductance Ca2+-activated K+ channels (IKCa1,
KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity
over KV, BKCa, SKCa, Na+, CRAC and
Cl- channels. Suppresses the reactivation of lymphocytes by
mitogenic stimuli.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Wulff et al
(2000) Design of a potent and selective inhibitor of the
intermediate-conductance Ca2+-activated K+ channel,
IKCa1: a potential immunosuppressant. Proc.Natl.Acad.Sci. USA 97
8151. Schilling and Eder (2007) TRAM-34 inhibits nonselective cation
channels. Pflugers Arch. 454 559. Wang et al (2007)
An intermediate-conductance Ca2+-activated K+ channel
mediates B lymphoma cell cycle progression induced by serum. Pflugers Arch. 454
945.
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or by Research Area
Keywords: TRAM 34, Potassium Channels, Highly Selective IKCa1 Channel Inhibitor, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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