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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowP2X ReceptorsarrowAntagonists
Cat.No. Product Name
2464 TNP-ATP triethylammonium salt
Price and Availability

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TNP-ATP triethylammonium salt
Chemical Name: 2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate tetratriethylammonium salt

Biological Activity:

High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors with IC50 values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7.

Technical Data:

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M.Wt: 1123.04
Formula: C16H13N8O19P3.C24H64N4
Storage: Desiccate at -20°C
Solubility: Soluble to 10 mM in Water
CAS No: [61368-63-6]

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    • Certificate of Analysis / MSDS:

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    Product/Material Safety Data Sheet: View current batch

    References:

    Virginio et al (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors. Mol.Pharmacol. 53 969. Lewis et al (1998) 2¢,3¢-O-(2,4,6-trinitrophenyl) adenosine 5¢-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 124 1463. Thomas et al (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 509.2 411.
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    Keywords: TNP-ATP Triethylammonium Salt, Ligand-gated Ion Channels, Potent, Selective P2X Antagonist, TNPATP Triethylammonium Salt, Tocris Bioscience
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