TMPH Hydrochloride | Ligand-gated Ion Channels | Neuronal Nicotinic Receptor Antagonist

Category:

Cat.No.	Product Name
2438	TMPH hydrochloride

Price and Availability

Click here for full price details of
TMPH hydrochloride

Other Information:

Sold under licence from the University of Florida Research Foundation Inc.

Chemical Name: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate

Biological Activity:

Potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). Displays little inhibition of muscle-type (α1β1gd) or α7 receptors.

Technical Data:

M.Wt:	305.88
Formula:	C₁₆H₃₁NO₂.HCl
Storage:	Desiccate at RT
Solubility:	Soluble to 100 mM in Water
Purity:	>98%
CAS No:	[849461-90-1]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

For specific/earlier batch please select:

Product/Material Safety Data Sheet: View current batch

For specific/earlier batch please select:

References:

Papke et al (2005) The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Mol.Pharmacol. 67 1977.

View related products by Pharmacological Action or by Research Area

Keywords: TMPH Hydrochloride, Ligand-gated Ion Channels, Neuronal Nicotinic Receptor Antagonist, Tocris Bioscience

Literature in this Area

Scientific Reviews

Nicotinic ACh Receptors
Request Copy | Download PDF

Signal Transduction Guide

	A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
View PDF

Product Feature

Nicotinic Receptors

Key nicotinic receptor compounds now available from Tocris include:

2737 TC 2559 difumarate

Selective partial agonist at α4β2 receptors

2303 PNU 282987

Selective α7 nAChR agonist

1029 Methyllycaconitine

α7 neuronal nicotinic receptor antagonist

View Product Feature

New Products in this Area

	2905	TB 21007
	α5-selective GABA_A inverse agonist
	2738	Org 20599
	Positive allosteric modulator and direct agonist of GABA_A receptors
	2805	Diazepam
	Benzodiazepine agonist
	2832	Midazolam hydrochloride
	Benzodiazepine agonist
	2972	A 438079 hydrochloride
	Competitve P2X₇ antagonist
	2736	Sazetidine A dihydrochloride
	Subtype-selective α4β2 receptor desensitiser
	2929	PEPA
	Allosteric potentiator of AMPA receptor desensitisation
	2973	Piracetam
	Nootropic; modulates Na⁺-flux at AMPA receptors
	2734	U 89843A
	Positive allosteric modulator of GABA_A
	2903	Granisetron hydrochloride
	5-HT₃ antagonist
	2782	TCS 46b
	Orally active, subtype-selective NR1A/NR2B antagonist
	2931	Spinorphin
	Potent P2X₃ antagonist
	2851	Nefiracetam
	Cognitive enhancer
	2770	Philanthotoxin 74
	GluR1/2 selective AMPA antagonist
	2891	Ondansetron hydrochloride
	Selective 5-HT₃ antagonist
	2820	(+)-Tubocurarine chloride
	Nicotinic receptor antagonist
	2843	Mecamylamine hydrochloride
	Non-competitive nicotinic receptor antagonist
	2810	Carbamoylcholine chloride
	Cholinergic receptor agonist
	1521	LY 233053
	Competitive NMDA receptor antagonist
	2745	U 93631
	GABA_A receptor antagonist
	2785	Strychnine hydrochloride
	Competitive glycine receptor antagonist
	2737	TC 2559 difumarate
	Selective partial agonist at α4β2 receptors
	2809	Acetylcholine chloride
	Endogenous neurotransmitter
	2681	17-PA
	Antagonist of neurosteroid potentiation and direct gating of GABA_A
	2722	Catestatin
	Inhibitor of nicotinic cholinergic-stimulated catecholamine secretion
	2701	YM 90K hydrochloride
	Selective AMPA antagonist
	2723	Anti-NR1
	Antibody recognising rat NR1 subunits
	2720	Anti-NR2A
	Antibody recognising mouse NR2A subunits
	2687	Pentylenetetrazole
	CNS stimulant
	2274	PPPA
	Competitive NR2A antagonist
	2450	NF 157
	Selective P2Y₁₁/P2X₁ antagonist
	2531	Ganaxolone
	Potent, positive allosteric modulator of GABA_A receptors
	2530	PPDA
	Subtype-selective NR2C/NR2D antagonist
	2548	NF 110
	Potent P2X₃ antagonist
	2056	Anti-phospho-NR2A (Ser¹²³²)
	Antibody recognising rat NR2A subunits phosphorylated at Ser¹²³²
	2049	Anti-glutamate receptor δ1/2
	Antibody recognising rat glutamate receptor δ1 and δ2 subunits
	2062	Anti-KA2
	Antibody recognising rat KA2 subunits
	2048	Anti-GluR6/7
	Antibody recognising rat GluR6 and GluR7 subunits
	2047	Anti-GluR5
	Antibody recognising rat GluR5 subunits
	2046	Anti-GluR4
	Antibody recognising rat GluR4 subunits
	2041	Anti-phospho-GluR1 (Ser⁸³¹)
	Antibody recognising rat GluR1 subunits phosphorylated at Ser⁸³¹
	2060	Anti-NR3B
	Antibody recognising mouse NR3B subunits
	2059	Anti-NR3A
	Antibody recognising rat NR3A subunits
	2054	Anti-NR1, alternative CT
	Antibody recognising rat NR1 subunits with alternative C-terminus

for new product e-alerts

User ID
Password