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Category:
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Enzymes PhosphatasesPTP
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Cat.No.
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Product Name
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2754 |
TCS 401
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Price and Availability
Click here for full price details of
TCS 401
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Chemical Name:
2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3
-c]pyridine-3-carboxylic acid hydrochloride |
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Biological Activity:
Selective inhibitor of protein-tyrosine
phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, >
2000, > 2000 and > 2000 μM for PTP1B,
CD45 D1D2, PTPβ,
PTPe
D1, SHP-1, PTPα
D1 and LAR D1D2 respectively).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Iversen et al
(2000) Structure-based design of a low molecular weight, nonphosphorus,
nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem. 275 10300. Andersen et al (2002)
Discovery and SAR of a novel selective and orally bioavailable nonpeptide
classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
J.Med.Chem. 45 4443.
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View related products by Pharmacological Action
or by Research Area
Keywords: TCS 401, Phosphatases, Selective Inhibitor Of PTP1B, TCS401, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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