DL-TBOA | Neurotransmitter Transporters | Potent, Selective Non-transportable Inhibitor Of EAATs | DLTBOA

Category:

Cat.No.	Product Name
1223	DL-TBOA

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DL-TBOA

Other Information:

Sold for research purposes under licence from Suntory Ltd

Chemical Name: DL-threo-b-Benzyloxyaspartic acid

Biological Activity:

A potent, competitive, non-transportable blocker of excitatory amino acid transporters with high selectivity for EAATs versus ionotropic and metabotropic glutamate receptors (IC₅₀/K_i values are 70, 6, 6, 4.4 and 3.2 μM for EAAT1, EAAT2, EAAT3, EAAT4 and EAAT5 respectively).

Technical Data:

M.Wt:	239.23
Formula:	C₁₁H₁₃NO₅
Storage:	Desiccate at -20°C
Solubility:	Soluble to 100 mM in DMSO and to 10 mM in Water
Purity:	>98%

Resources:

Certificate of Analysis / MSDS:

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References:

Shimamoto et al (1998) DL-threo-β-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol.Pharmacol. 53 195. Jabaudon et al (1999) Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin. Proc.Natl.Acad.Sci.USA 96 8733. Shimamoto et al (2000) Syntheses of optically pure β-hydroxyaspartate derivatives as glutamate transporter blockers. Bioorg.Med.Chem.Lett. 10 2407. Shigeri et al (2001) Effects of threo-β-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5). J.Neurochem. 79 297.

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Keywords: DL-TBOA, Neurotransmitter Transporters, Potent, Selective Non-transportable Inhibitor Of EAATs, DLTBOA, Tocris Bioscience

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