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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowGABAA ReceptorsarrowAgonists
Cat.No. Product Name
0181 TACA  
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TACA
Chemical Name: trans-4-Aminocrotonic acid

Biological Activity:

The trans-isomer of CACA. Potent GABAA agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABAC agonist.

Technical Data:

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M.Wt: 101.1
Formula: C4H7NO2
Storage: Store at RT
Solubility: Soluble to 100 mM in Water
CAS No: [38090-53-8]

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    References:

    Johnston et al (1975) cis and trans-4-Aminocrotonic acid as GABA analogues of restricted conformation. J.Neurochem. 24 157. Johnston et al (1996) GABAC receptors: relatively simple transmitter-gated ion channels. TiPS 17 319. Chebib et al (1997) Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br.J.Pharmacol. 122 1551.
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    Keywords: TACA, Ligand-gated Ion Channels, GABAA Agonist. Also GABA-T Substrate & GABA Uptake Inhibitor, Tocris Bioscience
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