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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowPolyamine SitearrowAntagonists
Cat.No. Product Name
0635 Synthalin sulfate
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Synthalin sulfate
Chemical Name: N,N'-1,10-Decanediylbisguanidine sulfate

Biological Activity:

An effective non-competitive NMDA receptor antagonist in vivo and in vitro; may bind to more than one site, one of which is the polyamine site.

Technical Data:

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M.Wt: 354.47
Formula: C12H28N6.H2SO4
Storage: Store at RT
Solubility: Soluble to 5 mM in Water
CAS No: [301-15-5]

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    • Certificate of Analysis / MSDS:

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    Product/Material Safety Data Sheet: View current batch

    References:

    Reynolds et al (1992) 1,10-Bis(guanidino)decane inhibits N-methyl-D-aspartate responses in vitro and in vivo. J.Pharmacol.Exp.Ther. 259 626. Reynolds (1992) Interactions between zinc and spermidine on the N-methyl-D-aspartate receptor complex:  clues to the mechanism of action of 1,10-bis(guanidino)decane and pentamidine. J.Pharmacol.Exp.Ther. 263 632.
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    Keywords: Synthalin Sulfate, Ligand-gated Ion Channels, Non-competitive NMDA Antagonist, Tocris Bioscience
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