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Category:
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7TM Receptors Adrenergic ReceptorsAlpha-2 ReceptorsAntagonists
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Cat.No.
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Product Name
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0631 |
Spiroxatrine
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Price and Availability
Click here for full price details of
Spiroxatrine
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Chemical Name:
8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1
,3,8-triazaspiro[4,5]decan-4-one |
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Biological Activity:
5-HT1A antagonist. More
active and selective than spiperone. Also a very potent α2 adrenergic receptor
ligand.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Nelson and Taylor (1986) Spiroxatrine: a selective serotonin 1A
receptor antagonist. Eur.J.Pharmacol. 124 207. Schoeffter and
Hoyer (1988) Centrally acting hypotensive agents with affinity for 5-HT1A
binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf
hippocampus. Br.J.Pharmacol. 95 975. Bylund et al
(1992) Pharmacological characteristics of α2-adrenergic receptors:
comparison of pharmacologically defined subtypes with subtypes identified by
molecular cloning. Mol.Pharmacol. 42 1.
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View related products by Pharmacological Action
or by Research Area
Keywords: Spiroxatrine, Adrenergic Receptors, Potent A2 Ligand , Tocris Bioscience
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Purity To Rely On
When choosing reagents for an experiment, the prime consideration is often to obtain the highest quality products available.
Unlike other suppliers, our in-house QC team carry out multiple analytical tests to thoroughly assess the purity of our reagents before they are offered for sale.
This accurate purity data is available on a batch-specific basis for every product via our website. At Tocris we work hard to ensure that we always supply to the highest possible standards of purity.
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