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Category: EnzymesarrowKinasesarrowProtein Kinase C
Cat.No. Product Name
0633 D-erythro-Sphingosine (synthetic)  
Price and Availability

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D-erythro-Sphingosine (synthetic)
Chemical Name: trans-D-erythro-2-Amino-4-octadecene-1,3-diol

Biological Activity:

Inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.

Technical Data:

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M.Wt: 299.5
Formula: C18H37NO2
Storage: Store at RT
Solubility: Soluble to 5 mM in DMSO and to 50 mM in Ethanol
CAS No: [123-78-4]

Resources:

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    References:

    Merrill et al (1989) Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry 28 3138. Grossman (1990) Sphingosine inhibition and promotion of histamine release from isolated rat mast cells. Agents Actions 31 171.
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    Keywords: D-erythro-Sphingosine (synthetic), Kinases, Protein Kinase C Inhibitor, Derythro-Sphingosine (synthetic), Tocris Bioscience
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