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Category:
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7TM Receptors Sphingosine-1-phosphate Receptors
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Cat.No.
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Product Name
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1370 |
Sphingosine-1-phosphate
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Price and Availability
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Sphingosine-1-phosphate
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Chemical Name:
(E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadec
ene-1,3-diol |
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Biological Activity:
Endogenous second messenger involved
in the control of cell proliferation and motility, and Ca2+
mobilisation. Binds to receptors in the novel endothelial differentiation gene
(EDG) G protein-coupled receptor family (EDG-1, -3, -5, -6 and -8). Effectors
regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain
phosphatase and focal adhesion kinase.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
van Koppen et al (1996) Activation of a high affinity Gi protein-coupled plasma
membrane receptor by sphingosine-1-phosphate. J.Biol.Chem. 271
2082. Pyne and Pyne (2000) Sphingosine 1-phosphate signalling via the
endothelial differentiation gene family of G-protein-coupled receptors.
Pharmacol.Ther. 88 115. Van Brocklyn et al (2000)
Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.
Blood 95 2624. Essler et
al (2002) Sphingosine 1-phosphate dynamically regulates myosin light chain
phosphatase activity in human endothelial cells. Cell.Signal. 14
607.
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Keywords: Sphingosine-1-phosphate, Sphingosine-1-phosphate Receptors, Bioactive Lipid, Binds EDG Receptors, Tocris Bioscience
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