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Chemical Name:N-Acetyl-L-aspartyl-L-glutamic acid
Biological Activity:
The most abundant peptide neurotransmitter in the mammalian CNS. A
weak activator of NMDA receptors, and a highly selective agonist for mGlu3
receptors. Neuroprotective under non-hydrolysing conditions in vivo.
Wroblewskaet al (1997) N-Acetylaspartylglutamate selectively
activates mGluR3 receptors in transfected cells. J.Neurochem. 69
174. Nealeet al (2000) N-Acetylaspartylglutamate: the most
abundant peptide neurotransmitter in the mammalian central nervous system.
J.Neurochem. 75 443. Thomaset al (2000) N-Acetylated
α-linked acidic dipeptidase converts N-acetylaspartylglutamate
from a neuroprotectant to a neurotoxin. J.Pharmacol.Exp.Ther. 295
16.
