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Category:
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Cellular Processes and Components Signal TransductionG-proteins (small)
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Cat.No.
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Product Name
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2849 |
SecinH3
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Price and Availability
Click here for full price details of
SecinH3
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Chemical Name:
N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triaz
ol-1-yl]phenyl]-2-(phenylthio)acetamide |
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Biological Activity:
Sec7-specific GEF inhibitor that displays
selectivity for small GEFs of the cytohesin family (IC50 values are
2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2,
hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively).
Inhibits insulin signalling via inhibition of insulin receptor substrate
protein (IRS) phosphorylation.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Hafner et al
(2006) Inhibition of cytohesins by secinH3 leads to hepatic insulin resistance.
Nature 444 941. Fuss et al (2006) The cytohesin
Steppke is essential for insulin signalling in Drosophila. Nature 444
945.
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View related products by Pharmacological Action
or by Research Area
Keywords: SecinH3, Signal Transduction, Sec7-specific GEF Inhibitor (cytohesins), Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Purity To Rely On
When choosing reagents for an experiment, the prime consideration is often to obtain the highest quality products available.
Unlike other suppliers, our in-house QC team carry out multiple analytical tests to thoroughly assess the purity of our reagents before they are offered for sale.
This accurate purity data is available on a batch-specific basis for every product via our website. At Tocris we work hard to ensure that we always supply to the highest possible standards of purity.
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