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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowAcetylcholine (Nicotinic) ReceptorsarrowOther Acetylcholine
Cat.No. Product Name
2736 Sazetidine A dihydrochloride
Price and Availability

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Sazetidine A
Chemical Name: 6-[5-[(2S)-2-Azetidinylmethoxy]-3-pyridinyl]-5-hexyn-1- ol dihydrochloride

Biological Activity:

Subtype-selective α4β2 nicotinic acetylcholine receptor desensitiser (Ki values are 0.41, 0.61 and 10,000 nM for rat α4β4, human α4β2 and rat α3β4 receptor subtypes respectively). Causes receptor desensitisation without first activating it, an inhibitory action termed silent desensitisation.

Technical Data:

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M.Wt: 333.25
Formula: C15H22Cl2N2O2
Storage: Store at +4°C
Solubility: Soluble to 50 mM in Water
Purity: >98%
CAS No: [820231-95-6]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Xiao et al (2006) Sazetidine-A, a novel ligand that desensitizes α4β2 nicotinic acetylcholine receptors without activating them. Mol.Pharmacol. 70 1454.
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    Keywords: Sazetidine A, Ligand-gated Ion Channels, Subtype-selective A4b2 Receptor Desensitiser, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Nicotinic ACh Receptors
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
    View PDF
    Product Feature
    Nicotinic Receptors
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