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Category:
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7TM Receptors Peptides (Hypothalamic/Pituitary Hormones)CRF Receptors
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Biological Activity:
Corticotropin-releasing
factor (CRF) receptor agonist. Ki values are 9.4, 9.9, and 3.8 nM
for inhibition of 125I-[Δ-Tyr1]astressin binding to hCRF-R1, rCRF-R2α and mCRF-R2β respectively.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Montecucchi
and Henschen (1981)
Amino acid composition and sequence analysis of sauvagine, a new active peptide
from the skin of PHYLLOMEDUSA SAUVAGEI. Int.J.Pept.Protein Res. 18
113. Eckart et al (1999) Actions of CRF and its analogues.
Curr.Med.Chem. 6 1035. Perrin and Vale (1999)
Corticotropin releasing factor receptors and their ligand family.
Ann.N.Y.Acad.Sci. 885 312.
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Keywords: Sauvagine, Peptides (Hypothalamic / Pituitary Hormones), CRF Agonist, Tocris Bioscience
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Selective, non-peptide CRF1 antagonist
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