|
Category:
|
Enzyme-Linked Receptors Receptor Tyrosine Kinases (RTKs)VEGFR
|
|
Cat.No.
|
Product Name
|
|
1459 |
SU 4312
|
| Alternative name(s): |
DMBI |
|
|
Price and Availability
Click here for full price details of
SU 4312
|
|
Chemical Name:
3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-i
ndol-2-one |
|
|
Biological Activity:
Potent
and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50
values are 0.8 and 19.4 μM respectively). Selective over EGFR
and c-Src tyrosine kinases.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
|
References:
Zaman et al
(1998) Tyrosine kinase activity of purified recombinant cytoplasmic domain of
platelet-derived growth factor β-receptor
(β-PDGFR) and discovery of a novel
inhibitor of receptor tyrosine kinases. Biochem.Pharmacol. 57 57.
Sun et al (1998) Synthesis and biological evaluations of
3-substituted indol-2-ones: a novel class of tyrosine kinase inhibitors that
exhibit selectivity toward particular receptor tyrosine kinases. J.Med.Chem. 41
2588. Kendall et al (1999) Vascular endothelial growth factor
receptor KDR tyrosine kinase activity is increased by autophosphorylation of
two activation loop tyrosine residues. J.Biol.Chem. 274 6453.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: SU 4312, Receptor Tyrosine Kinases (RTKs), Potent Inhibitor Of VEGFR Tyrosine Kinase, DMBI, SU4312, Tocris Bioscience
|
|
Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Product Feature
Kinase Inhibitors
Key kinase Inhibitors available from Tocris include:
|
