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Category:
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Cellular Processes and Components Signal TransductionCytokine and NFkB SignallingAP-1
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Cat.No.
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Product Name
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2476 |
SR 11302
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Price and Availability
Click here for full price details of
SR 11302
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Chemical Name:
(E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethy
l-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid |
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Biological Activity:
Inhibitor of activator protein-1 (AP-1)
transcription factor activity that displays antitumour effects in vivo. Does
not activate transcription from the retinoic acid response element (RARE) and
displays no activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Fanjul et al (2002) A new class of
retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372
107. Huang et al (1997) Blocking activator protein-1 activity,
but not activating retinoic acid response element, is required for the
antitumor promotion effect of retinoic acid. Proc.Natl.Acad.Sci.USA 94
5826. Shiohara et al (1999) Effects of novel RAR- and
RXR-selective retinoids on myeloid leukemic proliferation and differentiation
in vitro. Blood 93 2057.
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or by Research Area
Keywords: SR 11302, Signal Transduction, Inhibitor Of AP-1 Transcription Factor; Antitumour Agent, SR11302, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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