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Category: Cellular Processes and ComponentsarrowSignal TransductionarrowNitric Oxide SignallingarrowNO Donors / Precursors
Cat.No. Product Name
0598 SNAP  
Price and Availability

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SNAP
Chemical Name: (S)-Nitroso-N-acetylpenicillamine

Biological Activity:

A stable analogue of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t½ of 37h.

Technical Data:

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M.Wt: 220.24
Formula: C7H12N2O4S
Storage: Desiccate at -20°C
Solubility: Soluble to 100 mM in DMSO
CAS No: [79032-48-7]

Resources:

  • Certificate of Analysis / MSDS:

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    References:

    Bauer and Fung (1991) Differential thermodynamic effects and tolerance properties of nitroglycerin and S-nitrosothiol in experimental heart failure. J.Pharmacol.Exp.Ther. 256 249. Cross et al (1994) Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor. Neuropharmacology 33 915. Ekblad and Sundler (1997) Motor responses in rat ileum evoked by nitric oxide donors vs. field stimulation: modulation by pituitary adenylate cyclase-activating peptide, forskolin and guanylate cyclase inhibitors. J.Pharmacol.Exp.Ther. 283 23. Ferrero et al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779.

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    Keywords: SNAP, Signal Transduction, A Stable Analogue Of Endogenous S-nitroso Compounds, Tocris Bioscience

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