Tocris Bioscience
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Category: 7TM ReceptorsarrowGABAB ReceptorsarrowAgonists
Cat.No. Product Name
0379

SKF 97541  

Alternative name(s): CGP 35024
Price and Availability

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SKF 97541
Chemical Name: 3-Aminopropyl(methyl)phosphinic acid

Biological Activity:

A very potent GABAB agonist, at least ten times more active than baclofen (Cat. No. 0417). Also GABAC antagonist.

Technical Data:

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M.Wt: 137.12
Formula: C4H12NO2P
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Water
CAS No: [127729-35-5]

Resources:

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    References:

    Seabrook et al (1990) Electrophysiological characterization of potent agonists and antagonists on pre- and postsynaptic GABAB receptors on neurones in brain slices. Br.J.Pharmacol. 101 949. Froestl et al (1995) Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J.Med.Chem. 38 3297. Bon and Galvan (1996) Electrophysiological characterization of GABAB agonists and antagonists in dorso-lateral septal neurones in vitro. Br.J.Pharmacol. 118 961. Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319.

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    Keywords: SKF 97541, GABAB Receptors, Extremely Potent GABAB Agonist, CGP 35024, SKF97541, Tocris Bioscience

    Literature in this Area
    Scientific Reviews
    GABA Receptors
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    I am grateful for your honesty and courtesy. The principles of Tocris are very different to that of your competitors who, in fact, have put our inhibitor on the market without any approval, exhibiting a pirate policy and a total absence of ethics..”
    Researcher, University of Pisa, Italy
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