|
Category:
|
Enzymes Transferases
|
|
Cat.No.
|
Product Name
|
|
0512 |
SKF 91488 dihydrochloride
|
|
|
|
Price and Availability
Click here for full price details of
SKF 91488 dihydrochloride
|
|
Chemical Name:
4-(N,N-Dimethylamino)butylisothiourea dihydrochloride |
|
|
Biological Activity:
This homologue of dimaprit (Cat. No. 0506) is a strong inhibitor
of histamine N-methyltransferase, with no histamine agonist activity.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
|
|
|
References:
Beaven and Shaff (1979) New inhibitors of histamine
N-methyl-transferase. Biochem.Pharmacol. 28 183. Beaven and
Shaff (1979) Inhibition of histamine methylation in vivo by the
dimaprit analog SKF compound 91488. Agents Actions 9 455. Ohuri
et al (1992) Histamine N-methyl transferase controls the contractile
response of guinea pig trachea to histamine. J.Pharmacol.Exp.Ther. 261
1268. Aiello et al (1997) Effects of two
histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent
antinociception. Naunyn-Schmied.Arch.Pharmacol. 355 354.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: SKF 91488 Dihydrochloride, Transferases, Histamine N-methyltransferase Inhibitor, SKF91488 Dihydrochloride, Tocris Bioscience
|
|
Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
|
