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Chemical Name:2,3,4,5-Tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzaze
pine-7,8-diol hydrobromide
Biological Activity:
Selective
dopamine D1-like receptor partial agonist (IC50 values
are 19.7 and 2425 nM for binding to D1-like and D2-like
receptors respectively). Centrally active following systemic administration in
vivo.
Briggset al (1991) Activation of
the 5-HT1C receptor expressed in Xenopus oocytes by the
benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 104 1038. Neumeyeret al (1992) Stereoisomeric probes for the D1 dopamine
receptor: synthesis and characterization of R-(+) and S-(-)
enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
and its 6-bromo analogue. J.Med.Chem. 35 1466. Meyer and
Schults (1993) Dopamine D1 receptor family agonists,
SK&F38393, SK&F77434, and SK&F82958, differentially affect
locomotor activities in rats. Pharmacol.Biochem.Behav. 46 269.
