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Category: Cellular Processes and ComponentsarrowSignal TransductionarrowNitric Oxide SignallingarrowNO Donors / Precursors
Cat.No. Product Name
0756 SIN-1 chloride  
Alternative name(s): 3-Morpholinylsydnoneimine chloride
Price and Availability

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SIN-1 chloride
Chemical Name: Amino-3-morpholinyl-1,2,3-oxadiazolium chloride

Biological Activity:

This compound (the active product of the prodrug molsidomine, SIN-10) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin.

Technical Data:

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M.Wt: 206.63
Formula: C6H11ClN4O2
Storage: Desiccate at +4°C
Solubility: Soluble to 100 mM in Water and to 100 mM in DMSO
Purity: >99%
CAS No: [16142-27-1]

Resources:

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    • Certificate of Analysis / MSDS:

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    References:

    Tanayama et al (1974) Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats. Xenobiotica 4 175. Nishikawa et al (1982) Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite. J.Pharmacol.Exp.Ther. 220 183. Maurice and Heslam (1990) Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol.Pharmacol. 37 671.
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    Keywords: SIN-1 Chloride, Signal Transduction, Water-soluble NO Donor, 3-Morpholinylsydnoneimine Chloride, SIN1 Chloride, Tocris Bioscience
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