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Category:
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7TM Receptors Glutamate (Metabotropic) ReceptorsGroup I mGlu ReceptorsAntagonists
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Cat.No.
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Product Name
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1214 |
SIB 1893
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Price and Availability
Click here for full price details of
SIB 1893
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Chemical Name:
2-Methyl-6-(2-phenylethenyl)pyridine |
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Biological Activity:
A highly selective non-competitive antagonist for the metabotropic
glutamate mGlu5 receptor subtype; displays an IC50 value
of 0.3 μM at hmGlu5, compared with > 100 μM at hmGlu1b, hmGlu2, hmGlu6,
hmGlu7 and hmGlu8. Centrally active upon systemic
administration in vivo. Positive allosteric modulator at mGlu4
receptors.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Varney et
al (1999) SIB-1757 and SIB-1893: selective, noncompetitive antagonists of
metabotropic glutamate receptor type 5. J.Pharmacol.Exp.Ther. 290
170. Chapman et al (2000) Anticonvulsant activity of two
metabotropic glutamate group I antagonists selective for the mGlu5 receptor:
2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine
(SIB 1893). Neuropharmacology 39 1567. Mathiesen et al
(2003) Positive allosteric modulation of the human metabotropic glutamate
receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br.J.Pharmacol. 138
1026.
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Keywords: SIB 1893, Glutamate (Metabotropic) Receptors, MGlu5 Antagonist & Positive Allosteric Modulator At MGlu4, SIB1893, Tocris Bioscience
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