SDZ 220-581 | Ligand-gated Ion Channels | Competitive NMDA Antagonist, Centrally Active | SDZ220-581

Category:

Ion Channels

Ligand-gated Ion Channels

Glutamate (Ionotropic) Receptors

NMDA Selective

NMDA Site

Antagonists

Cat.No.	Product Name
1250	SDZ 220-581

Price and Availability

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SDZ 220-581

Other Information:

Sold with the permission of Novartis Pharma AG

Chemical Name: (S)-a-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl ]-3-propanoic acid

Biological Activity:

Competitive NMDA receptor antagonist (pK_i = 7.7). Centrally active following oral administration (ED₅₀ < 3.2 mg/kg for protection against MES-induced seizures).

Technical Data:

M.Wt:	369.74
Formula:	C₁₆H₁₇ClNO₅P
Storage:	Store at RT
Solubility:	Soluble to 50 mM in DMSO and to 100 mM in 1.1 eq. NaOH
Purity:	>98%
CAS No:	[174575-17-8]

Resources:

Certificate of Analysis / MSDS:

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References:

Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - I. Pharmacological characterization in vitro. Neuropharmacology 35 643. Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - II. Pharmacological characterization in vivo. Neuropharmacology 35 655. Bakshi et al (1999) Disruption of prepulse inhibition and increases in locomotor activity by competitive N-methyl-D-aspartate receptor antagonists in rats. J.Pharmacol.Exp.Ther. 288 643.

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Keywords: SDZ 220-581, Ligand-gated Ion Channels, Competitive NMDA Antagonist, Centrally Active, SDZ220-581, Tocris Bioscience

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