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Category:
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7TM Receptors Adenosine ReceptorsAntagonists
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Cat.No.
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Product Name
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2463 |
SCH 442416
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Price and Availability
Click here for full price details of
SCH 442416
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Chemical Name:
2-(2-Furanyl)-7-[3-(4-methoxyphenyl)propyl]-7H-pyrazolo
[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine |
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Biological Activity:
Extremely
selective adenosine A2A receptor antagonist that binds to human and
rat A2A receptors with high affinity (Ki values are 0.048
and 0.5 nM respectively). In vitro displays > 23000-fold selectivity for hA2A
over hA1 and minimal affinity for hA2B and hA3
receptors (IC50 > 10 μM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Toddle et al (2000)
Design, radiosynthesis, and biodistribution of a new potent and selective
ligand for in vivo imaging of the adenosine A2A receptor system
using positron emission tomography. J.Med.Chem. 43 4359.
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or by Research Area
Keywords: SCH 442416, Adenosine Receptors, Very Selective, High Affinity A2A Antagonist, SCH442416, Tocris Bioscience
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