Chemical Name:2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acet
onitrile
Biological Activity:
Potent
inhibitor of H+,K+-ATPase (IC50 = 20 nM);
binds to the K+ recognition site and is competitive with respect to
K+. Inhibits gastric acid secretion in vitro and in vivo.
Longet al (1983) Gastric
antisecretory and cytoprotective activities of SCH 28080. J.Pharmacol.Exp.Ther.
226 114. Scottet al (1987) Studies on the
mechanism of action of the gastric microsomal (H+K+)-ATPase
inhibitors SCH 32651 and SCH 28080. Biochem.Pharmacol. 36 97. Vaginet al (2002) SCH 28080, a K+-competitive inhibitor of the
gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+
access to the ion binding domain. Biochemistry 41 12755.
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