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Category:
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Ion Channels Transient Receptor Potential ChannelsTRPV
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Cat.No.
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Product Name
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1615 |
SB 366791
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Price and Availability
Click here for full price details of
SB 366791
Other Information:
Sold for
research purposes under agreement from GlaxoSmithKline
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Chemical Name:
4'-Chloro-3-methoxycinnamanilide |
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Biological Activity:
Potent,
selective and competitive vanilloid TRPV1 (VR1) receptor antagonist (pA2 =
7.71 at hVR1); antagonises hTRPV1 receptors activated by agonists, noxious
heat, but not protons. Displays selectivity over a wide range of receptors and
systems including CB1 and CB2 receptors, voltage-gated Ca2+
channels and the hyperpolarisation-activated current (Ih).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Fowler et al (2003) Inhibition of C6
glioma cell proliferation by anandamide, 1-arachidonylglycerol, and by a water
soluble phosphate ester of anandamide: variability in response and involvement
of arachidonic acid. Biochem.Pharmacol. 66 757. Gunthorpe et
al (2004) Identification and characterisation of SB-366791, a potent and
selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology 46
133. Gavva et al (2005) Proton activation does not alter
antagonist interaction with the capsaicin-binding pocket of TRPV1.
Mol.Pharmacol. 68 1524.
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View related products by Pharmacological Action
or by Research Area
Keywords: SB 366791, Transient Receptor Potential Channels, Potent, Selective, Competitive TRPV1 (VR1) Antagonist, SB366791, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
| “Our laboratory loves dealing with Tocris and consider many of the compounds you sell to be far better quality than the compounds that we have received from other companies. Once again, thank you very much..” Researcher, Albany Medical College, USA |
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