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Category:
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7TM Receptors Chemokine ReceptorsCXCR
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Cat.No.
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Product Name
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2724 |
SB 265610
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Price and Availability
Click here for full price details of
SB 265610
Other Information:
Sold for research purposes under agreement from
GlaxoSmithKline
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Chemical Name:
N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea |
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Biological Activity:
Potent CXCR2 antagonist that inhibits
CINC-1-mediated but not C5a-mediated Ca2+ mobilisation (IC50
values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and
attenuates neutrophil accumulation in inflammatory lung injury in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Auten et al
(2001) Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in
hyperoxia-exposed newborn rats. J.Pharmacol.Exp.Ther. 299 90. Milatovic
et al (2003) Impaired healing of nitrogen mustard wounds in CXCR2 null
mice. Wound Repair Regen. 11 213.
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or by Research Area
Keywords: SB 265610, Chemokine Receptors, Potent CXCR2 Antagonist, SB265610, Tocris Bioscience
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