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Category:
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7TM Receptors 5-HT Receptors5-HT7 Receptors
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Cat.No.
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Product Name
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2726 |
SB 258719 hydrochloride
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Price and Availability
Click here for full price details of
SB 258719
Other Information:
Sold for research purposes under agreement from
GlaxoSmithKline
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Chemical Name:
3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)pro
pyl]-N-methylbenzenesulfonamide hydrochloride |
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Biological Activity:
Selective 5-HT7 receptor
antagonist that displays > 100-fold selectivity over a range of other
receptors. Reverses the hypothermic effect of 5-CT in mice following i.p.
administration.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Forbes et
al (1998) (R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)propyl]benzenesulfonamide:
the first selective 5-HT7 receptor antagonist. J.Med.Chem. 41
655. Thomas et al (1998) Functional characterisation of the human
cloned 5-HT7 receptor (long form); antagonist profile of SB-258719.
Br.J.Pharmacol. 124 1300. Guscott et al (2003) The
hypothermic effect of 5-CT in mice is mediated through the 5-HT7
receptor. Neuropharmacol. 44 1031.
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Keywords: SB 258719, 5-HT Receptors, Selective 5-HT7 Antagonist, SB258719, Tocris Bioscience
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