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Category:
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7TM Receptors 5-HT Receptors5-HT2 Receptors5-HT2C
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Cat.No.
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Product Name
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1375 |
SB 228357
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Price and Availability
Click here for full price details of
SB 228357
Other Information:
Sold under
licence
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Chemical Name:
N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy
-6-(trifluoromethyl)-1H-indole-1-carboxamide |
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Biological Activity:
5-HT2C/2B receptor antagonist (pKi values
are 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C
receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI
hydrolysis model of 5-HT2C receptor function. Orally active in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Bromidge et al (2000) Biarylcarbamoylindolines are novel and
selective 5-HT2C receptor inverse agonists: identification of
5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline
(SB-243213) as a potential antidepressant/anxiolytic agent. J.Med.Chem. 43
1123. Reavill et al (1999) Attenuation of haloperidol-induced
catalepsy by a 5-HT2C receptor antagonist. Br.J.Pharmacol. 126
572.
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Keywords: SB 228357, 5-HT Receptors, 5-HT2C / 2B Antagonist / Inverse Agonist, SB228357, Tocris Bioscience
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